SkinMedica HA5 Smooth and Plump Lip System Review - For Fuller Plumper Lips Lip Plumper Updated August, 2022
Final Thoughts

Overall Score 63%

SkinMedica HA5 Smooth and Plump Lip System Review

Manufacturer’s Claim

This review examines SkinMedica HA5 Smooth and Plump Lip System. A two-step treatment which provides smoothing and hydrating benefits and plumps the lips. It enhances rosiness, and visibly smooths fine lines. Step 1 smoothes the lips and Step 2 plumps the lips.


HA5 Lip Smooth Ingredients:

  • Grape Flower Cell Extract
  • Vibrio Alginolyticus Ferment Filtrate
  • Alteromonas Ferment Extract
  • Porphyridium Cruentum Extract
  • Plankton Extract
  • Trehalose
  • Urea
  • Serine
  • Algin
  • Caprylyl Glycol
  • Pullulan Disodium Phosphate
  • Potassium Phosphate
  • Pentylene Glycol
  • Polymethylsilsesquioxane
  • Glyceryl Polyacrylate
  • Sea Water
  • Sucrose Palmitate
  • Tocopheryl Acetate
  • Hydroxyacetophenone
  • Polysorbate 60
  • Propanediol
  • Potassium Sorbate
  • Citric Acid
  • Isohexadecane
  • Polysorbate 80
  • Silica
  • Decyl Glucoside
  • Tromethamine
  • Ethylhexylglycerin
  • Phenoxyethanol
  • Disodium EDTA
  • Water
  • Dimethicone
  • HDI/Trimethylol Hexyllactone Crosspolymer
  • Glycerin
  • Polysilicon- 11
  • Bis-PEG-8 Dimethicone
  • Sodium Acrylate Taurate Copolymer
  • Sodium Hyaluronate Crosspolymer
  • Hydrolyzed Hyaluronic Acid
  • Sodium Hyaluronate
  • Whey Protein
  • Butylene Glycol

Grape Flower Cell Extract protects, maintains, and regenerates epidermal adult stem cells. Vibrio Alginolyticus Ferment Filtrate acts as a regenerating, revitalizing agent and takes action as an anti-wrinkle agent. Alteromonas Ferment Extract provides benefits such as to hydrate, repair, restore and protect the skin. Porphyridium Cruentum Extract provides anti-aging skincare benefits. Plankton Extract provides anti-aging and anti-wrinkle benefits.

HA5 Lip Plump Ingredients:

  • Soybean Oil
  • Benzyl Nicotinate
  • Ethylene/Propylene/Styrene Copolymer
  • Butylene/Ethylene/Styrene Copolymer
  • Propyl Methyl Methoxy Benzofuran
  • Flavor/Aroma
  • Phenoxyethanol, Hydroxymethyl Phenyl

Soybean Oil is used for its benefits as a skin conditioning and skin firming agent. Benzyl Nicotinate provides skin oxygenation benefits. Cinnamal is an oily liquid that gives cinnamon its spice.

There is no active ingredient in the lip plump formula to generate a plumping effect, it should contain 10% active ingredients with a minimum of 5 patented clinically proven ingredients, such as Volulip, Argireline NP, Syn-Coll, Stay-C 50,  and Trylagen PCB.

Volulip An is an active substance containing a plant extract and a natural modified matrikine-mimetic peptide to plump lips by hyaluronic acid synthesis. It provides an improvement of the internal and superficial lip texture with a visible impact on the lip shape and volume, provides hydration and softness as well as an anti-aging and anti-sagging effect. Argireline NP is a peptide (Acetyl hexapeptide-8) which inhibits SNARE complex formation and catecholamine release, resulting in the reduction of the existing facial wrinkles. Demonstrated effectiveness against their development with regular use, by clinical studies of twice-a-day treatment, the severity of wrinkles around the eyes decreased up to 17% after 15 days treatment.

Syn-Coll is a patented, synthetic tripeptide which helps slow down the skin aging process. By mimicking the body’s own mechanism, boosts collagen production and protects against collagen degradation. After only one month of application, Syn-Coll outperformed a market benchmark in a fight against lines and wrinkles. At 2.5% concentration, it reveals a more lifted, sculpted look, and refined pore appearance for smoother, younger-looking skin.
Stay-C 50 consists of a stabilized (phosphorylated) sodium salt of an L-ascorbic acid. The esterification (a chemical reaction that forms at least one ester) of ascorbic acid, protects vitamin C from destruction by oxidation. Trylagen PCB a combination of active peptides and proteins that provide an effective treatment to restore the collagen levels of beauty, youth, and mature skin, maintaining an adequate long-lasting collagen function that will ensure a beautiful, healthy and youthful skin.


This product may be applied as needed throughout the day. For optimal results, it may be used three (or more) times per day. Step 1 – the lip soother should be applied around the lips and lip contour. Step 2 – the lip plumper should be applied to the lips, staying within the natural lip line.


The price of this product is $68.00  for 0.05 oz. available to be purchased online at various online third-party retailers. We are unable to allocate if any discounts are given.


We could not find any information regarding the manufacturer’s guarantee, which is somewhat concerning as to how much confidence the manufacturer has in this product and how effective this product is.

SkinMedica HA5 Smooth and Plump Lip System Review – The Bottom Line

The consumer reviews of this product are pleasing and the manufacturer provides many easy options for the consumer to purchase this product online. However, there is a lot of doubt regarding the effectiveness of this product as it should contain 10% active ingredients with a minimum of 5 patented clinically proven ingredients. The lip plump formula does not contain an active ingredient to generate a plumping effect. The manufacturer does not offer the consumer any guarantee and neither does the manufacturer offer any discounts.

Reviewed & delivered by our panel of experts at Reviewy.